Progressive supranuclear palsy is a movement disorder with prominent tau neuropathology. Brain diseases with abnormal tau deposits are called tauopathies, the most common of which is Alzheimer's disease. Environmental causes of tauopathies include repetitive head trauma associated with some sports. To identify common genetic variation contributing to risk for tauopathies, we carried out a genome-wide association study of 1,114 individuals with PSP and 3,247 controls followed by a second stage in which we genotyped 1,051 cases and 3,560 controls for the (...) stage 1 SNPs that yielded P ≤ 10-3. We found significant previously unidentified signals associated with PSP risk at STX6, EIF2AK3 and MOBP. We confirmed two independent variants in MAPT affecting risk for PSP, one of which influences MAPT brain expression. The genes implicated encode proteins for vesicle-membrane fusion at the Golgi-endosomal interface, for the endoplasmic reticulum unfolded protein response and for a myelin structural component. © 2011 Nature America, Inc. All rights reserved. (shrink)

What determines whether an action is right or wrong? Morality, Rules, and Consequences: A Critical Reader explores for students and researchers the relationship between consequentialist theory and moral rules. Most of the chapters focus on rule consequentialism or on the distinction between act and rule versions of consequentialism. Contributors, among them the leading philosophers in the discipline, suggest ways of assessing whether rule consequentialism could be a satisfactory moral theory. These essays, all of which are previously unpublished, provide students in (...) moral philosophy with essential material and ask key questions on just what the criteria for an adequate moral theory might be. (shrink)

David Émile Durkheim, life and times -- Moral solidarity and the new social science: Durkheim's study of the individual in society and society in the individual -- Morality, law, the state, and politics -- Establishing a social science -- Education as social science and cultural politics -- The "revelation" of religion -- Odds and ends: Durkheim's unfinished works on morality and the family and his war writings -- Further readings.

This collection of Habermas's recent essays on philosophical topics continues the analysis begun in The Philosophical Discourse of Modernity. In a short introductory essay, he outlines the sources of twentieth-century philosophizing, its major themes, and the range of current debates. The remainder of the essays can be seen as his contribution to these debates.Habermas's essay on George Herbert Mead is a focal point of the book. In it he sketches a postmetaphysical, intersubjective approach to questions of individuation and subjectivity. In (...) other essays, he develops his distinctive, communications-theoretic approach to questions of meaning and validity. The book as a whole expands on his earlier efforts to define a middle ground between nostalgic revivals of metaphysical conceptions of reason and radical deconstructions of reason. Jürgen Habermas is Professor of Philosophy at the University of Frankfurt.The Essays: The Horizon of Modernity is Shifting. Metaphysics after Kant. Themes in Postmetaphysical Thinking. Toward a Critique of the Theory of Meaning. Peirce and Communication. The Unity of Reason in the Diversity of Its Voices. Individuation through Socialization: On George Herbert Mead's Theory of Subjectivity. Philosophy and Science as Literature? (shrink)

First published in 1990, _Existentialism_ is widely regarded as a classic introductory survey of the topic, and has helped to renew interest in existentialist philosophy. The author places existentialism within the great traditions of philosophy, and argues that it deserves as much attention from analytic philosophers as it has always received on the continent.

Why do gardens matter so much and mean so much to people? That is the intriguing question to which David Cooper seeks an answer in this book. Given the enthusiasm for gardens in human civilization ancient and modern, Eastern and Western, it is surprising that the question has been so long neglected by modern philosophy. Now at last there is a philosophy of gardens. David Cooper identifies garden appreciation as a special human phenomenon distinct from both from the (...) appreciation of art and the appreciation of nature. He discusses the contribution of gardening and other garden-related pursuits to "the good life." And he distinguishes the many kinds of meanings that gardens may have, from their representation of nature to their spiritual significance. A Philosophy of Gardens will open up this subject to students and scholars of aesthetics, ethics, and cultural and environmental studies, and to anyone with a reflective interest in things horticultural. (shrink)

Zoos and aquariums have an enormous global reach and hence an ability to craft meaningful conservation action for threatened species, implement educational strategies to encourage human engagement, development and behavior change, and conduct scientific research to enhance the husbandry, roles and impacts of the living collection. The recreational role of the zoo is also vast- people enjoy visiting the zoo and this is often a shared experience amongst family and friends. Evaluating how the zoo influences this “captive audience” and extending (...) its reach to include a compassionate approach to animals and people can further enhance the mission, value, and relevance of their work. The modern zoo’s current aims—Conservation, Education, Research and Recreation—provide useful foundations for the activities that zoos conduct at a local and national level. However, to improve sustainability of their actions and outcomes, we feel that Wellbeing should become the fifth aim of the modern zoo for the future- both from an animal perspective and from a human perspective. This paper provides discussion and review of how Wellbeing is already a substantial part of what zoos work on as well as posing the idea of altering the Recreation aim of the zoo to one of Engagement, which potentially is more measurable and therefore can allow zoo researchers and managers further options for the collection of evidence on the local and global reach of their zoo’s aims. Education, Engagement, Conservation, Research and Wellbeing provide a more complete picture of the roles of the modern zoo for the animals, human visitors and workforce, and to society more widely. (shrink)

This paper reviews the actual and potential use of social media in emergency, disaster and crisis situations. This is a field that has generated intense interest. It is characterised by a burgeoning but small and very recent literature. In the emergencies field, social media (blogs, messaging, sites such as Facebook, wikis and so on) are used in seven different ways: listening to public debate, monitoring situations, extending emergency response and management, crowd-sourcing and collaborative development, creating social cohesion, furthering causes (including (...) charitable donation) and enhancing research. Appreciation of the positive side of social media is balanced by their potential for negative developments, such as disseminating rumours, undermining authority and promoting terrorist acts. This leads to an examination of the ethics of social media usage in crisis situations. Despite some clearly identifiable risks, for example regarding the violation of privacy, it appears that public consensus on ethics will tend to override unscrupulous attempts to subvert the media. Moreover, social media are a robust means of exposing corruption and malpractice. In synthesis, the widespread adoption and use of social media by members of the public throughout the world heralds a new age in which it is imperative that emergency managers adapt their working practices to the challenge and potential of this development. At the same time, they must heed the ethical warnings and ensure that social media are not abused or misused when crises and emergencies occur. (shrink)

Efforts to conserve endangered species of animal are, in some important respects, at odds with Buddhist ethics. On the one hand, being abstract entities, species cannot suffer, and so cannot be proper objects of compassion or similar moral virtues. On the other, Buddhist commitments to equanimity tend to militate against the idea that the individual members of endangered species have greater value than those of less-threatened ones. This paper suggests that the contribution of Buddhism to the issue of species conservation (...) should not, however, be discounted. It argues, on the contrary, that Buddhist traditions, in reminding us of the moral significance of the suffering of individual animals, add an important dimension to debates concerning the ethical justification of efforts to conserve endangered species. (shrink)

Contrary to what many philosophers believe, Calvinism neither makes the problem of evil worse nor is it obviously refuted by the presence of evil and suffering in our world. Or so most of the authors in this book claim. While Calvinism has enjoyed a resurgence in recent years amongst theologians and laypersons, many philosophers have yet to follow suit. The reason seems fairly clear: Calvinism, many think, cannot handle the problem of evil with the same kind of plausibility as other (...) more popular views of the nature of God and the nature of God's relationship with His creation. This book seeks to challenge that untested assumption. With clarity and rigor, this collection of essays seeks to fill a significant hole in the literature on the problem of evil. (shrink)

In his quest to solve 'the ever-disquieting riddle of existence', Schopenhauer explored almost every dimension of human existence, developing a darkly compelling worldview that found deep resonance in contemporary literature, music, philosophy, and psychology. This is the first comprehensive biography of Schopenhauer written in English. Placing him in his historical and philosophical contexts, David E. Cartwright tells the story of Schopenhauer's life to convey the full range of his philosophy. He offers a fully documented portrait in which he explores (...) Schopenhauer's fractured family life, his early formative influences, his critical loyalty to Kant, his personal interactions with Fichte and Goethe, his ambivalent relationship with Schelling, his contempt for Hegel, his struggle to make his philosophy known, and his reaction to his late-arriving fame. (shrink)

???Everyone agrees that the moral features of things supervene on their natural features??? , 22). Everyone is wrong, or so I will argue. In the first section, I explain the version of moral supervenience that Smith and others argue everyone should accept. In the second section, I argue that the mere conceptual possibility of a divine command theory of morality is sufficient to refute the version of moral supervenience under consideration. Lastly, I consider and respond to two objections, showing, among (...) other things, that while DCT is sufficient to refute this version of moral supervenience it is not necessary. (shrink)

David E. Cooper elucidates Nietzsche's educational views in detail, in a form that will be of value to educationalists as well as philosophers. In this title, first published in 1983, he shows how these views relate to the rest of Nietzsche's work, and to modern European and Anglo-Saxon philosophical concerns. For Nietzsche, the purpose of true education was to produce creative individuals who take responsibility for their lives, beliefs and values. His ideal was human authenticity. David E. Cooper (...) sets Nietzsche's critique against the background of nineteenth-century German culture, yet is concerned at the same time to emphasize its bearing upon recent educational thought and policy. (shrink)

Meaning is one of our most central and most ubiquitous concepts. Anything at all may, in suitable contexts, have meaning ascribed to it. In this wide-ranging book, David Cooper departs from the usual focus on linguistic meaning to discuss how works of art, ceremony, social action, bodily gesture, and the purpose of life can all be meaningful. He argues that the notion of meaning is best approached by considering what we accept as explanations of meaning in everyday practice and (...) shows that in these situations we are explaining the appropriate fit of an item - whether a word or an artwork - with something larger than or outside of itself. This fuller account of meaning explores questions of the meaning of meaning and tackles issues such as whether meaning is just a misleading 'folk' term for something more basic, whether there really is meaning at all, and whether we should strive for meaning or let our lives 'just be' rather than mean. By taking the problem of meaning out of the technical philosophy of language and providing a more general account, Cooper is able to offer new insights into the import, function, and status of meaning that will be of interest not only to philosophers of language but to students and philosophers working in areas such as epistemology and metaphysics. (shrink)

This paper sympathetically examines the neglected virtue-centric idea that the primary location of beauty is in bodily expressions of human virtues, so that things like buildings are beautiful only because of an appropriate relationship they have to beautiful people. After a brief history of the idea as articulated by, for example, Kant, it is then distinguished from accounts of beauty with which it might be confused, such as the view that something is beautiful only if it helps to instil virtue. (...) In the central part of the paper, the attractions of virtue-centrism are articulated. These primarily consist in its explanatory power. It is argued, too, that virtue-centrism steers attractively between a rigidly conservative attitude towards beauty and an anything goes one. The final sections respond to some likely objections, the last of which provides an opportunity for correcting an impression that my formulation of the virtue-centrist idea might have given. CiteULike Connotea Del.icio.us What's this? (shrink)

This study examines the way ethical decisions are made in controversial cases at The Courier-Journal in Louisville, Kentucky, to see if codes of ethics can be efective at a newspaper known for its commitment to ethics. The study concludes that a code is efective in that environment especially on conflict-of-interest questions. A critical factor in the code's efectiveness is an ethical culture in which editors support ethical standards vigorously and foster a process that encourages newsroom debate over controversial cases.

This study builds on prior research investigating the antecedents of firm supererogation. Examining vehicle recalls in the U.S. automobile industry from 1966 to 2010 reveals that surveillance-based government enforcement programs can have widespread industry effects on a specific type of supererogatory action, firm volunteerism. Specifically, increases in government surveillance are associated with firms going beyond what is legally required of them by initiating voluntary product recalls for defects not covered in existing government regulation. Such effects are shown to be unique (...) among surveillance efforts as other government enforcement activities, such as standards-based regulation, are revealed to have a negative association with firm supererogation. (shrink)

This paper examines how a person’s life may be shaped by living with a sense of the mystery of reality. What virtues, if any, are encouraged by such a sense? The first section rehearses a radical ”doctrine of mystery’, according to which reality as it anyway is, independently of human perspectives, is ineffable. It is then argued that a sense of mystery may provide ”measure’ for human lives. For it is possible for a life to be ”consonant’ with this sense (...) -- through exercising humility, for example -- and even to emulate mystery. A further section corrects a misunderstanding about the connection between a sense of mystery and the virtues it invites, while a final section considers the relationship between living with mystery and religious faith. (shrink)

Published in German during the last 15 years, the 13 essays in this volume provide readers with valuable knowledge of the much discussed theme of hermeneutics today. Gadamer was an early student of Martin Heidegger and has been a lifelong friend and interpreter. These essays are an outgrowth of Gadamer's Truth and Method. They can be understood, however, independently of it. Gadamer's standpoint is a blend of Hegel's and Heidegger's, with his own independent development in part. The book contains a (...) long and highly competent introduction by the editor, David E. Linge, who has translated most of the essays. - Choice, on back cover. (shrink)

This popular text has now been revised to ensure that it continues to meet the needs of the growing number of people interested in all the main philosophical traditions of the world. Introduces all the main philosophical systems of the world, from ancient times to the present day. Now includes new sections on Indian and Persian thought and on feminist and environmental philosophy. The preface and bibliography have also been updated. Written by a highly successful textbook author.

'Everyone agrees that the moral features of things supervene on their natural features' (Smith (1994), 22). Everyone is wrong, or so I will argue. In the first section, I explain the version of moral supervenience that Smith and others argue everyone should accept. In the second section, I argue that the mere conceptual possibility of a divine command theory of morality (DCT) is sufficient to refute the version of moral supervenience under consideration. Lastly, I consider and respond to two objections, (...) showing, among other things, that while DCT is sufficient to refute this version of moral supervenience it is not necessary. (shrink)

This book teaches students how to make the difficult ethical decisions that journalists routinely face.

A study is reported testing two hypotheses about a close parallel relation between indicative conditionals, if A then B , and conditional bets, I bet you that if A then B . The first is that both the indicative conditional and the conditional bet are related to the conditional probability, P(B|A). The second is that de Finetti's three-valued truth table has psychological reality for both types of conditional— true , false , or void for indicative conditionals and win , lose (...) , or void for conditional bets. The participants were presented with an array of chips in two different colours and two different shapes, and an indicative conditional or a conditional bet about a random chip. They had to make judgements in two conditions: either about the chances of making the indicative conditional true or false or about the chances of winning or losing the conditional bet. The observed distributions of responses in the two conditions were generally related to the conditional probability, supporting the first hypothesis. In addition, a majority of participants in further conditions chose the third option, “void”, when the antecedent of the conditional was false, supporting the second hypothesis. (shrink)

This paper sympathetically explores Daoism's relevance to environmental philosophy and to the aspiration of people to live in a manner convergent with nature. After discussing the Daoist understanding of nature and the dao (Way), the focus turns to the implications of these notions for our relationship to nature. The popular idea that Daoism encourages a return to a way of life is rejected. Instead, it is shown that the Daoist proposal is one of living more than people generally do in (...) the modern, technological world, and of allowing other beings to do so as well. These themes are clarified in a final section, inspired by some Daoist remarks, devoted to the relationship of human beings with animals. (shrink)

The week, twenty-five years ago, of the Apollo spacecraft's return visit to the moon was described by Richard Nixon as the greatest since the Creation. Across the Atlantic, a French Academician judged the same event to matter less than the discovery of a lost etching by Daumier. Attitudes to technological achievement, then, differ. And they always have. Chuang-Tzu, over 2,000 years ago, relates an exchange between a Confucian passer-by and a Taoist gardener watering vegetables with a bucket drawn from a (...) well. ‘Don't you know that there is a machine with which 100 beds are easily watered in a day?’—‘How does it work?’—‘It's a counterbalanced ladle’—‘too clever to be good … all machines have to do with formulae, artificiality [which] destroy native ingenuity … and prevent the Tao from residing peacefully in one's heart’. ‘Engines of mischief, in the words of the Luddite song, or testaments to ‘the nobility of man [as] the conqueror of matter’, in those of Primo Levi, the products of technology continue to inspire phobia and philia. (shrink)

Personal values have long been associated with individual decision behavior. The role played by personal values in decision making within an organization is less clear. Past research has found that managers tend to respond to ethical dilemmas situationally. This study examines the relationship between personal values and the ethical dimension of decision making using Partial Least Squares (PLS) analysis. The study examines personal values as they relate to five types of ethical dilemmas. We found a significant positive contribution of altruistic (...) values to ethical decision making and a significant negative contribution of self-enhancement values to ethical decision making. (shrink)

The aim of this study was to examine the predictions of three theories of human logical reasoning, (a) mental model theory, (b) formal rules theory (e.g., PSYCOP), and (c) the probability heuristics model, regarding the inferences people make for extended categorical syllogisms. Most research with extended syllogisms has been restricted to the quantifier “All” and to an asymmetrical presentation. This study used three-premise syllogisms with the additional quantifiers that are used for traditional categorical syllogisms as well as additional syllogistic figures. (...) The predictions of the theories were examined using overall accuracy as well as a multinomial tree modelling technique. The results demonstrated that all three theories were able to predict response selections at high levels. However, the modelling analyses showed that the probability heuristics model did the best in both Experiments 1 and 2. (shrink)

As discussion intensifies, and critics exploit what they see as a serious press abuse of anonymous sources, this article explores current practices and policies, as well as examines justification for and danger of anonymous source usage. Seven guidelines are listed and discussed which may help editors and reporters decide whether to use the anonymous source: editor authorization, just cause, last resort, fullest possible identification, proportionality, just intentions, and second source verification.

This study uses theories of moral reasoning and moral competence to investigate how university codes of ethics, perceptions of ethical culture, academic pressure from significant others, and ethics pedagogy are related to the moral development of students. Results suggest that ethical codes and student perceptions of such codes affect their perceptions of the ethical nature of the cultures within these institutions. In addition, faculty and student discussion of ethics in business courses is significantly and positively related to moral competence among (...) students. Our results point to the need to further examine the connections among academic institutional structures, ethics pedagogy, and students’ moral development. (shrink)

The new paradigm in the psychology of reasoning adopts a Bayesian, or prob- abilistic, model for studying human reasoning. Contrary to the traditional binary approach based on truth functional logic, with its binary values of truth and falsity, a third value that represents uncertainty can be introduced in the new paradigm. A variety of three-valued truth table systems are available in the formal literature, including one proposed by de Finetti. We examine the descriptive adequacy of these systems for natural language (...) indicative condi- tionals and bets on conditionals. Within our framework the so-called “defective” truth table, in which participants choose a third value when the antecedent of the indicative conditional is false, becomes a coherent response. We show that only de Finetti’s system has a good descriptive fit when uncer- tainty is the third value. (shrink)

Linking abstract principles and concrete cases is not always easy. Beginning deductively with ethical theory requires an a priori choice of ethical principles which, when applied, may not take account of the complexity of real problems. But beginning with cases can result in a situationalism in which the normative role of ethical principles is slighted. Casuistry, a case-centered methodology, offers one way to bridge this gap. Casuistry's bottom-up strategy develops policy guidelines out of case analysis, building a middle ground between (...) practice and principle. This article identifies the key features of casuistry and its link to ethical theory. The development of a code of ethics and the use of anonymous sources at a daily newspaper test casuistry's relevance for journalism ethics. (shrink)

The week, twenty-five years ago, of the Apollo spacecraft's return visit to the moon was described by Richard Nixon as the greatest since the Creation. Across the Atlantic, a French Academician judged the same event to matter less than the discovery of a lost etching by Daumier. Attitudes to technological achievement, then, differ. And they always have. Chuang-Tzu, over 2,000 years ago, relates an exchange between a Confucian passer-by and a Taoist gardener watering vegetables with a bucket drawn from a (...) well. ‘Don't you know that there is a machine with which 100 beds are easily watered in a day?’—‘How does it work?’—‘It's a counterbalanced ladle’—‘too clever to be good … all machines have to do with formulae, artificiality [which] destroy native ingenuity … and prevent the Tao from residing peacefully in one's heart’. ‘Engines of mischief, in the words of the Luddite song, or testaments to ‘the nobility of man [as] the conqueror of matter’, in those of Primo Levi, the products of technology continue to inspire phobia and philia. (shrink)